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drug and its active metabolites in the target organ in a myocardium. Memberships in Scientific Societies: Since 2014 membership in Czech Society for Clinical and Experimental Pharmacology and Toxicology. Vavrova A, Jansova H, Mackova E, Machacek M, Haskova P, Tichotova L, Sterba M and Simunek. Celkem bylo pipraveno 67 ltek, z nich je 31 originlnch. 174 kB, sthnout, posudek oponenta armDr. The phase I metabolism of Bp4eT was studied in vitro and in vivo. Both oxidative metabolites were also detected in vivo together with the newly found hydroxylated metabolic product. Title of Doctoral Thesis Analytical evaluation of drugs and drug candidates from the group of iron chelating agents High performance liquid chromatography (hplc) ranks among the most important analytical techniques in the field of pharmaceutical analysis thanks to its robustness and the ability to separate. At the beginning, novel hplc-UV methods were developed and validated for the determination of in vitro stability of 2-hydroxy-1- (N4mT) and di(2-pyridyl)ketone-4,4- dimethyl-3-thiosemicarbazone (Dp44mT) in plasma. Truktry metabolitov boli spoiatku navrhnut na zklade dt zskanch analzou s vysokm rozlenm a presnm urenm hmoty a vzpät potvrden pomocou tdia ich fragmentcie. Princp chelatcie eleza je taktie spomnan aj v prpade mechanizmu inku dexrazoxanu jedinho klinicky dostupnho kardioprotektva schopnho chrni myokard pred toxickmi inkami antracyklinov.
Fze medzi ktor patrili produkty oxidcie thiokarbonylovej skupiny, N-demethylcie, hydroxylcie, otvorenia cyklohexylu spojenho s adciou vody, a zrove rzne kombincie tchto reakci. (IF 2015:.008) ( Q1 ). . The compounds were tested in vitro for antifungal and antibacterial activity. At the same time the earlier prepared condensation product of rhodanine and ketones derived mainly from substituted acetylpyrazines were further tested for biological properties. V dal sti prce byla vnovna pozornost pprav kondenzanch produkt N-substituovanho rhodaninu s aromatickmi a heterocyklickmi aldehydy nebo ketony. Abstract v anglitin: abstract Charles University in Prague, Faculty of Pharmacy in Hradec Krlov Department of Pharmaceutical Chemistry and Drug Control Candidate Mgr.